ETHYL (2-FORMAMIDO-1,3-THIAZOL-4-YL) GLYOXYLATE

PRODUCT IDENTIFICATION
CAS NO. 64987-03-7

ETHYL (2-FORMAMIDO-1,3-THIAZOL-4-YL)GLYOXYLATE

EINECS NO. 265-299-4
FORMULA C8H8N2O4S
MOL WT. 228.22

H.S. CODE

  
SMILES

 

TOXICITY

  
SYNONYMS 2-(2-Formylaminothiazole-4yl)-Glyoxylic Acid Ethyl Ester;
Ethyl 2-(formylamino)-4-thiazoleglyoxylate; Ethyl 2-(Formylamino)-4-Thiazole Glyoxylate; EFTG;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE light yellow powder
MELTING POINT 230 - 232 C (Decomposes)
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

 Health: 2; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

  
FLASH POINT > 110.00 C
STABILITY Stable under ordinary conditions.

APPLICATIONS
Glyoxylic acid is the smallest alpha-keto acid which has a ketone group on the carbon atom next to the acid group. If the ketone group is on the second carbon next to the acid group, it is called beta-keto acid. Glyoxylic acid has dual functional compound with both carboxylic acid and aldehyde. One more example of small mole weight alpha-keto acid is pyruvic acid which has methyl branch. Glyoxylic acid is present in the body as the primary precursor of oxalic acid and as an intermediate in the conversion of glycolic acid to glycine. The metabolic pathway to convert fat to carbohydrateby in certain microorganisms and plants is called glyoxylate cycle. Glyoxylates, any salt, anion, or ester of glyoxylic acid, are important in biochemical research.

Pure glyoxylic acid is a liquid with melting point of -93 C and boiling Point of 111 C. Glyoxylic acid is formed in commerce by oxidation reaction of glycolic acid or by ozonolysis (oxidaton) and reduction of maleic acid. Ozonolysis which uses ozone is to cleave the alkene bonds. An example of ozonolysis in commerce is the production of odd carbon number carboxylic acids such as azelaic acid and pelargonic acid and simple carboxylic acids such as formic acid and oxalic acid.

Allantoin, active in skin-softening (keratolytic effect) and rapid cell regeneration by precipitating proteins on skin is the diureide of glyoxylic acid. In industrial field, it is used as a basic chemical for the synthesis of other chemical products of acids, esters, cyclic compounds. Applications filed includes aroma compounds, agrochemicals, pharmaceuticals, and polymers.

Ethyl 2-(formylamino)-4-thiazole glyoxylate is used as an intermediate for manufacturing pharmaceuticals (side chain of cephalosprins).

SALES SPECIFICATION

APPEARANCE

 light yellow powder

ASSAY

 98.5% min

MOISTURE

0.3% max
MELTING POINT 230 - 232 C
TRANSPORTATION
PACKING

 

HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 24/25/28A/37/45